Beta Adrenergic Receptor Agonist

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Contents 1 More Specific Terms 2 Adverse-effects 3 Drug-interactions 4 Mechanism-of-action 5 More General Terms 6 Additional Terms 7 References

More Specific Terms

• beta-1 adrenergic receptor agonist
• beta-2 adrenergic receptor agonist
• bitolterol (Tornalate)
• ephedrine
• epinephrine; adrenaline (Sus-Phrine, Vapronefrin, Epifrin, Glaucon)
• isoetharine (Bronkosol, Bronkometer)
• isoproterenol
• long-acting beta adrenergic receptor agonist (LABA)
• metaproterenol (Alupent, Metaprel, Dey-Dose)
• pirbuterol (Maxair)

Adverse-effects

• hypokalemia, intracellular shift of K+
• metabolic acidosis
• hypomagnesemia
• tachycardia
• tremor
• anxiety
• palpitations
• hypertension
• cardiac arrhythmias
• exacerbation of prostatism
• paradoxic bronchospasm to aerosolized beta-adrenergic agents (especially long-acting agents, salmeterol, formoterol [2]

• tachyphylaxis
• preservatives & propellants

• adverse effects more likely in elderly & in patients with cardiovascular, hepatic & neurologic disorders
  
• drug adverse effects of adrenergic receptor agonists
• drug adverse effects of beta-adrenergic receptor agonists

Drug-interactions

• beta adrenergic agonists may potentiate the effects of MAO inhibitors & tricyclic antidepressants

Mechanism-of-action

• stimulation of cAMP formation in selected cell population

More General Terms

• adrenergic receptor agonist

Additional Terms

• antiarrhythmic agent, Group II
• beta adrenergic receptor

References

1. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 741
2. Prescriber's Letter 12(9): 2005 The Safety of Long-Acting Beta-2 Agonists in Patients with Asthma Detail-Document#: [1] (subscription needed) [2]
   - US Department of Health and Human Services. National Institutes of Health. National Heart, Lung and Blood Institute. Expert Panel Report: Guidelines for the Diagnosis and Management of Asthma-Update on selected topics 2002. [3]
3. Salpeter SR et al, Meta-analysis: Effect of long-acting beta agonists on severe asthma exacerbations and asthma-related deaths. Ann Intern Med 2006; 144:904 PMID: [4]
   - Glassroth J The role of long-acting beta-agonists in the management of asthma. Analysis, meta-analysis, and more analysis, Ann Intern Med 2006; 144:936 PMID: [5]
4. Bateman E et al, Effects of adding salmeterol in inhaled corticosteroids on serious asthma-related events. Ann Intern Med 2008, June 3 PMID: [6]
   - Weiss KB Drug safety and salmeterol: The controversy continues. Ann Intern Med 2008, June 3 PMID: [7]

beta adrenergic receptor agonist