Beta 2 Adrenergic Receptor

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Pathology 5 More General Terms 6 Additional Terms 7 Internet Database 8 References

Function

• beta-adrenergic receptor
• binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine
• binds SLC9A3R1 & GPRASP1
• palmitoylated; may reduce accessibility of Ser-345 & Ser- 346 by anchoring Cys-341 to the plasma membrane
• agonist stimulation promotes depalmitoylation & further allows Ser-345 & Ser-346 phosphorylation
• phosphorylated by & BARK upon <A2282>agonist</A2282> stimulation, which mediates <A2240>homologous</A2240> <A10547>desensitization</A10547> of the receptor
• -mediated phosphorylation seems to facilitate phosphorylation by <A129083>BARK</A129083>
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• belongs to the G-protein coupled receptor 1 family

Compartment

• cell membrane; multi-pass membrane protein

Pathology

• polymorphic forms of ADRB2 could impart some form of nocturnal asthma
• polymorphisms (C & G) alleles associated with different mortality when treated with beta-blocker after acute coronary syndrome

More General Terms

• beta adrenergic receptor

Additional Terms

• beta-2 adrenergic receptor agonist

Internet Database

Kegg: [1]
OMIM: 109690
Prosite: [2]
Prosite: [3]
UniProt: [4]
Entrez gene: 154

References

1. Molecular Cell Biology (2nd ed) Darnell J; Lodish H & Baltimore D (eds), Scientific American Books, WH Freeman, NY 1990, pg 748
2. Principles of Neural Science, 3rd ed. Kandel ER, Schwartz JH & Jessell TM (eds), Elsevier NY 1991, pg 175
3. Lanfear DE, Jones PG, Marsh S, Cresci S, McLeod HL, Spertus JA. Beta2-adrenergic receptor genotype and survival among patients receiving beta-blocker therapy after an acute coronary syndrome. JAMA. 2005 Sep 28;294(12):1526-33. PMID: [5]
4. UniProt [6]
5. GeneReviews [7]
6. SeattleSNPs [8]

beta-2 adrenergic receptor; beta-2 adrenoreceptor; beta-2 adrenoceptor (ADRB2, ADRB2R, B2AR)