Beclomethasone

From Anvita Health Wiki

Contents 1 Introduction 2 Indications 3 Contraindications 4 Dosage 5 Pharmacokinetics 6 Adverse-effects 7 Mechanism-of-action 8 More General Terms 9 Internet Database 10 References

Introduction

• Tradenames: Vanceril, Beclovent.

Indications

• treatment of asthma ( inhaler)
• relief of rhinitis (nasal spray)
• prevention of recurrence of nasal polyps following surgical removal

Contraindications

• status asthmaticus
• hypersensitivity to beclomethasone, fluorocarbons or oleic acid in the formula
  

• pregnancy category = c
• safety in lactation = -
• safety in lactation = ?

Dosage

• inhaler: 2 puffs TID/ QID., 42 ug/ inhalation. 16.8 g

• Qvar: 40 & 80 ug/ inhalation; uses non- ozone-depleting hydrofluorohydrocarbons; smaller particle size; no spacer needed

• nasal spray: inhalation in affected nostril(s) BID- QID 42 ug/ inhalation. 16.8 g.

Pharmacokinetics

• inhaler:

• some improvement may occur within 1 week
• general 1-4 weeks required for significant improvement

• nasal spray: onset of action

• relief of symptoms generally occurs within a few days, but may take as long as 2 weeks
  

• elimination via liver

Adverse-effects

• Vanceril

• systemic absorption is low
• if correct technique is not used, hypothalamic- pituitary- adrenal function
• oral thrush is common especially if patients do not rinse after use
• irritation: cough, hoarseness, xerostomia
• rare (< 1%)

• skin rash, bronchospasm, difficulty swallowing

• Vancenase, Beconase

• irritation of nasal mucosa
• epistaxis
• rare (< 1%)

• headache, rhinorrhea, nasal stuffiness, sneezing, nasal ulceration & septal perforation
  

• drug adverse effects of glucocorticoids
• drug adverse effects of immunosuppressive agents

Mechanism-of-action

• nasal preparation

• does NOT inhibit IgE synthesis or mast cell degranulation
• inhibits cytokine production, arachidonate metabolism, inflammation & mast cell proliferation

More General Terms

• glucocorticoid
• antiasthmatic agent

Internet Database

PubChem: 2307
PubChem: 20469
PubChem: 2308
PubChem: 657383
PubChem: 217100

References

1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
2. Saunders Manual of Medical Practice, Rakel (ed), WB Saunders, Philadelphia, 1996, pg 85
3. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998 - not on National VA formulary
4. Kaiser Permanente Northern California Regional Drug Formulary, 1998
5. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
6. Prescriber's Letter 7(11):64 2000

beclomethasone (Vancenase, Beconase, Vanceril, Beclovent, Qvar)