Becaplermin

From Anvita Health Wiki

Contents 1 Introduction 2 Indications 3 Dosage 4 Adverse-effects 5 Mechanism-of-action 6 More General Terms 7 References

Introduction

• Tradename: Regranex. Recombinant platelet-derived growth factor-beta ( PDGF-beta).

Indications

• FDA approved for diabetic ulcers
• also useful for venous stasis ulcers

Dosage

• Apply gel to clean wound bed once a day.
• Cover with saline moistened dressing
• After 12 hours, rinse with saline or water & apply new dressing. Gel 0.01% in 2, 7.5 & 15 g tubes

Adverse-effects

• systemically available PDGF < 3%
• rash (2%)
• may be an increased risk of death from cancer in diabetic patients using Regranex (becaplermin) Gel [2]

Mechanism-of-action

• Aids in production of granulation tissue.

More General Terms

• platelet-derived growth factor subunit B
• recombinant protein
• dermatologic agent

References

1. Ortho-McNeil Pharmaceuticals
2. FDA MedWatch [1]

becaplermin (Regranex)