Bcl2 Adenovirus E1b 19kd Protein Interacting Protein 3 Like

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 More General Terms 5 Internet Database 6 References

Function

• induces apoptosis
• interacts with viral & cellular anti- apoptosis proteins
• can overcome the suppressors BCL-2 & BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis
• may function as a tumor suppressor
• inhibits apoptosis induced by BNIP3
• undergoes progressive proteolysis to an 11 kD C-terminal fragment, which is blocked by the proteasome inhibitor lactacystin
• self-associates
• interacts with BNIP3 & STEAP3
• interacts with human adenovirus-2 E1B 19 kD protein

Structure

• belongs to the NIP3 family

Compartment

• nucleus envelope
• endoplasmic reticulum
• mitochondrion
• single-pass membrane protein ( putative)

More General Terms

• mitochondrial protein
• nuclear protein
• membrane protein
• phosphoprotein

Internet Database

Entrez gene: 665
Kegg: [1]
OMIM: 605368
UniProt: [2]

References

UniProt [3]

BCL2/adenovirus E1B 19 kD protein-interacting protein 3-like; NIP3-like protein X; NIP3L; BCL2/adenovirus E1B 19 kD protein-interacting protein 3A; adenovirus E1B19K-binding protein B5 (BNIP3L, BNIP3A, BNIP3H, NIX)