Bax

From Anvita Health Wiki

Contents 1 Function 2 Compartment 3 More General Terms 4 Additional Terms 5 Internet Database 6 References

Function

• inhibits bcl-2 through formation of heterodimers
• binding of bcl-2 to Bax occurs via BH1 domain & BH2 domain
• Bax also forms homodimers
• oligomerization of bax leads to integration in the mitochondrial outer membrane & channel formation
• component of permeability transition pore complex ( PTPC)
• cooperates with constitutive mitochondrial protein adenosine nucleotide translocator-1 ( ANT-1) to increase mitochondrial membrane permeability & trigger cell death
• induces release of cytochrome c from mitochondria

Compartment

• translocates from cytosol to mitochondria during apoptosis

More General Terms

• bax subfamily protein
• membrane protein

Additional Terms

• ADP/ATP translocase-1 (adenine nucleotide translocator 1, ANT 1, ADP-ATP carrier protein 1, solute carrier family 25 member 4, heart/skeletal ADP/ATP carrier protein, SLC25A4, ANT1)
• apoptosis regulator Bcl-2; B-cell CLL/lymphoma-2 (bcl-2) protein (BCL2)
• bax gene
• cytochrome c (CYCS)

Internet Database

Prosite: [1]
UniProt: [2]
OMIM: 600040
Entrez gene: 581
Kegg: [3]
Kegg: [4]
Kegg: [5]
Kegg: [6]

References

1. Oltvai ZN, Milliman CL, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 1993 Aug 27;74(4):609-19. PMID: &dopt=Abstract
2. Martin SJ, Green DR, Cotter TG. Dicing with death: dissecting the components of the apoptosis machinery. Trends Biochem Sci. 1994 Jan;19(1):26-30. Review. PMID: [7]
3. Korsmeyer SJ. Regulators of cell death. Trends Genet. 1995 Mar;11(3):101-5. Review. PMID: [8]
4. Yin XM, Oltvai ZN, Korsmeyer SJ. BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature. 1994 May 26;369(6478):321-3. PMID: [9]
5. Marzo I et al Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. Science. 1998 Sep 25;281(5385):2027-31. PMID: [10]
6. Oda K, Arakawa H, Tanaka T, Matsuda K, Tanikawa C, Mori T, Nishimori H, Tamai K, Tokino T, Nakamura Y, Taya Y. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell. 2000 Sep 15;102(6):849-62. PMID: [11]
7. Antonsson B, Martinou JC. The Bcl-2 protein family. Exp Cell Res. 2000 Apr 10;256(1):50-7. Review. PMID: [12]
8. Entrez Gene [13]

Bcl-2 associated protein X (BAX)