Bak2 Protein

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 Notes 6 More General Terms 7 Internet Database 8 References

Function

• in the presence of an appropriate stimulus, accelerates apoptosis by binding to, & antagonizing the apoptosis repressor Bcl-2 or its adenovirus homolog E1B 19k protein
• forms heterodimers with Bcl-2, E1B 19k protein, & Bcl-XL

Structure

• intact BH3 domain is required by BIK, BID, BAK, BAD & BAX for their pro- apoptotic activity & for their interaction with anti- apoptotic members of the Bcl-2 family & apoptotic members of the Bcl-2 family
• belongs to the Bcl-2 family

Compartment

• membrane ( potential)

Expression

• expressed in a wide variety of tissues, with highest levels in the heart & skeletal muscle

Notes

• could be the product of a pseudogene
• deleted from UniProt database Aug 2010

More General Terms

• bax subfamily protein

Internet Database

Prosite: [1]
Prosite: [2]
Prosite: [3]
Prosite: [4]

References

1. UniProt [5]
2. Kiefer MC, Brauer MJ, Powers VC, Wu JJ, Umansky SR, Tomei LD, Barr PJ. Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak. Nature. 1995 Apr 20;374(6524):736-9. PMID: [6]

Bcl-2 homologous antagonist/killer 2; apoptosis regulator BAK-2 (BCL2L7P1 BAK2)