B Cell Lymphoid Neoplasm
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Contents |
More Specific Terms
- cutaneous B-cell lymphoma
- mature B-cell acute lymphocytic leukemia (ALL)
- peripheral B-cell lymphoid neoplasm
- precursor B-cell lymphoid neoplasm
Introduction
- Also see non-Hodgkin's lymphoma.
Classification
-
- aggressive
- highly aggressive
- Burkett lymphoma
- lymphoblastic lymphoma
- AIDS-related lymphoma
Genetics
- the bcl-7a gene is a site of recurrent breakpoint in high grade B cell lymphomas
- chromosomal translocation t(8;14;12)(q24.1;q32.3;q24.1) involving BCL7A, MYC & immunoglobulin gene region associated with B-cell non-Hodgkin lymphoma
- chromosomal translocation t(8;14)(p23.1;q21) involving MFHAS1 with a cryptic exon named '14q21 element' may be a cause of B-cell lymphoma, resulting fusion protein named 'chimeric MASL1' is tumorigenic in nude mice
- chromosomal translocation t(11;14)(q23;q32) involving DDX6 may be a cause of B-cell lymphoma
- chromosomal translocation t(3;14)(q27;q32) involving BCL6 with immunoglobulin gene regions may be a cause of B-cell non-Hodgkin lymphoma
- chromosomal translocation t(3;11)(q27;q23) involving BCL6 with POU2AF1/ OBF1 may be a cause of a form of B-cell leukemia
- other implicated genes MIRH1, BMI1
Complications
More General Terms
References
- Entrez Gene [1]
- UniProt [2]
- Medical Knowledge Self Assessment Program (MKSAP) 15, American College of Physicians, Philadelphia 2009
