Autophagy Related Protein 9b

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Alternative-splicing 5 Expression 6 Genetics 7 More General Terms 8 Internet Database 9 References

Function

• plays a role in autophagy ( putative)

Structure

• belongs to the ATG9 family

Compartment

• cytoplasmic vesicle, autophagosome membrane

Alternative-splicing

• named isoforms=3

Expression

• highly expressed in placenta ( trophoblast cells) & pituitary gland
• not expressed in vascular endothelium
• induced by hypoxia, leading to inhibit NOS3 expression

Genetics

• ATG9B gene is located on the opposite DNA strand of the NOS3 gene at chromosome 7q36
• the genes are oriented in a tail-to-tail configuration & the mRNAs encoding ATG9B & NOS3 are complementary for 662 nucleotides
• ATG9B transcription may a role in NOS3 transcription regulation

More General Terms

• membrane protein
• autophagy protein (autophagy-related protein)

Internet Database

Kegg: [1]
UniProt: [2]

References

UniProt [3]

autophagy-related protein 9B (APG9-like 2, nitric oxide synthase 3-overlapping antisense gene protein, protein sONE, ATG9B, APG9L2, NOS3AS)