Autoimmune Disease
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Contents |
More Specific Terms
- antiphospholipid syndrome (APS)
- autoimmune lymphoproliferative syndrome (ALPS, Canale-Smith syndrome)
- autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED); autoimmune polyglandular syndrome type 1
- autoimmune thyroid disease
- autoimmune vasculitis
- Behcet syndrome
- cancer-associated retinopathy syndrome (CAR)
- classic polyarteritis nodosa (PAN)
- Evan's syndrome
- Goodpasture's syndrome
- graft versus host disease (GVHD)
- Graves disease (Basedow's disease, exothalmic goiter)
- Hashimoto's thyroiditis; chronic lymphocytic thyroiditis; struma lymphomatosa; lymphadenoid goiter; primary myxedema
- immune or idiopathic thrombocytopenic purpura (ITP)
- Kawasaki disease; mucocutaneous lymph node disease
- Lambert-Eaton myasthenic syndrome (LEMS)
- lymphocytic (autoimmune) hypophysitis
- multiple sclerosis (MS)
- myasthenia gravis
- paraneoplastic brainstem encephalitis
- paraneoplastic cerebellar degeneration
- paraneoplastic limbic encephalitis
- paraneoplastic opsoclonus myoclonus ataxia; Kinsbourne syndrome; myoclonic encephalopathy of infants; dancing eyes-dancing feet syndrome
- paraneoplastic photoreceptor retinal degeneration
- Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infection (PANDAS)
- pemphigus foliaceus
- pemphigus vulgaris
- pernicious anemia
- polymyalgia rheumatica (PMR)
- primary biliary cirrhosis
- rheumatoid arthritis (RA)
- scleroderma (systemic sclerosis)
- Sjogren's syndrome (keratoconjunctivitis sicca, autoimmune epitheliitis)
- systemic lupus erythematosus
- Takayasu's arteritis; aortic arch syndrome; pulseless disease
- temporal arteritis (cranial arteritis, giant cell arteritis)
- Tn syndrome
- tropical spastic paraparesis
- Wegener's granulomatosis
Introduction
- A disease of autoimmunity.
Pathology
- secretion of IL-17 by T-helper cells ( Th17 cells)
- increased serum levels of FCGBP
Management
- immunosuppression of various forms
- investigational
- in mice, digoxin suppresses production of IL-17 & onset of experimental autoimmune encephalitis [1]
More General Terms
Additional Terms
Internet Database
OMIM: 109100
References
- Huh JR et al Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORt activity. Nature 2011 Apr 28; 472:486 PMID: [1]
- Solt LA et al. Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand. Nature 2011 Apr 28; 472:491 PMID: [2]
- Jetten AM. A helping hand against autoimmunity. Nature 2011 Apr 28; 472:421 PMID: [3] - Autoimmune Diseases (General): NIH Institute and Center Resources [4]
- National Guideline Clearinghouse EFNS guidelines on the treatment of cluster headache and other trigeminal-autonomic cephalalgias. European Federation of Neurological Societies ngc-guideline: [5]
