Atpase Wrnip1

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Alternative-splicing 4 Expression 5 More General Terms 6 Additional Terms 7 Internet Database 8 References

Function

• modulates initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis
• intrinsic ATPase activity
• sensor of DNA damage or of arrested replication forks
• regulates the extent of DNA synthesis
• interacts with POLD1, POLD2, POLD4, WRN.

Structure

• homooligomer, most likely an octamer Coompartment:
• colocalizes with WRN in granular structures in the nucleus

Alternative-splicing

• named isoforms=4

Expression

• ubiquitously expressed

More General Terms

• phosphoprotein
• adenosine triphosphatase (ATPase)
• oligomerizing protein

Additional Terms

• Werner syndrome ATP-dependent helicase (WRN, RECQ3, RECQL2)

Internet Database

OMIM: 608196
Prosite: [1]
UniProt: [2]

References

UniProt [3]

ATPase WRNIP1 (Werner helicase-interacting protein 1, WRNIP1, WHIP)