Atp Binding Cassette C13
From Anvita Health Wiki
Contents |
Function
Structure
- belongs to the binding-protein-dependent transport system permease family
- contains 1 ABC transmembrane type-1 domain
- contains sequences related to ABC transporter subfamily C, but lacks Walker A, Walker B, & signature C motifs, indicating that it is a nonfunctional ABC transporter
- translation of the cDNA in a different reading frame predicts a 93 amino acid peptide with signature C & Walker B motifs, but no Walker A motif
Compartment
- membrane ( putative)
Alternative-splicing
- named isoforms=5
- Some isoforms may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay
Expression
- highest expression in fetal liver & fetal spleen
- in the adult, highest levels are found in the ascending colon & transverse colon
- also expressed in brain, placenta, lung, liver, pancreas & ovary
- in bone marrow cells, levels are several fold higher than in peripheral blood leukocytes
- down-regulated by cell differentiation in certain leukemia cells
More General Terms
Internet Database
OMIM: 608835
Prosite: [1]
UniProt: [2]
Entrez gene: 150000
References
UniProt [3]
