Apolipoprotein B48

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Expression 4 Pathology 5 More General Terms 6 References

Function

• by analogy to apo B100, it is suggested that apo B48 may play a role in chylomicron transport

Structure

• apo B48 consists of the N-terminal 2152 residues of Apo B100
• it does not include recognition site for LDL receptor

Expression

• apo B48 is formed via intestine-specific post- transcriptional modification of the ApoB gene transcript ( mRNA editing) to generate new stop codon within the transcribed region

Pathology

• normally, very little B-48 is found in plasma of fasting individuals; however, in persons with defects in chylomicron remnant clearance (e.g. chronic renal failure), levels of B-48 are increased; this would imply role of the kidney in chylomicron remnant clearance

More General Terms

• apolipoprotein B

References

1. Mendelian Inheritance in Man (1990) MIM#107370
2. Primary Hyperlipoproteinemias, Steiner & Shafrir (eds), McGraw Hill, NY, 1991, pg 25
3. Tietz Textbook of Clinical Chemistry, 2nd ed. Burtis CA & Ashwood ER (eds), WB Saunders Co, Philadelphia PA, 1993, pg 1021

apolipoprotein b48