Apixaban

From Anvita Health Wiki

Contents 1 Introduction 2 Indications 3 Contraindications 4 Dosage 5 Monitor 6 Adverse-effects 7 Mechanism-of-action 8 Notes 9 More General Terms 10 Additional Terms 11 Internet Database 12 References

Introduction

• Not yet FDA approved Jan 2011.

Indications

• prevention of deep vein thrombosis after knee surgery
• embolic stroke prophylaxis for atrial fibrillation [3]

• better than warfarin [4]

Contraindications

• continued use of apixaban as thromboprophylaxis after hospitalization of medically ill patients [5]

Dosage

• 2.5 mg PO BID
• start 12-24 hours after surgery
• continue for 10-14 days

Monitor

• none required

Adverse-effects

• less bleeding than enoxaparin or warfarin

Mechanism-of-action

• direct inhibitor of factor Xa

Notes

• rivaroxaban is also a small molecule inhibitor of factor Xa administered orally

More General Terms

• anticoagulant

Additional Terms

• rivaroxaban (Xarelto)

Internet Database

PubChem: 10182969

References

1. Lassen MR et al Apixaban or enoxaparin for thromboprophylaxis after knee replacement. N Engl J Med 2009 Aug 6; 361:594. PMID: [1]
2. Lassen MR et al. Apixaban versus enoxaparin for thromboprophylaxis after hip replacement. N Engl J Med 2010 Dec 23; 363:2487. PMID: [2]
   - Hylek E. Therapeutic potential of oral factor Xa inhibitors. N Engl J Med 2010 Dec 23; 363:2559 PMID: [3]
3. Connolly SJ et al. for the AVERROES Steering Committee and Investigators. Apixaban in patients with atrial fibrillation. N Engl J Med 2011 Feb 10 <PubMed> PMID: [4] <Internet> [5]
4. Granger CB et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med 2011 Aug 28 PMID: [6]
   - Mega JL. A new era for anticoagulation in atrial fibrillation. N Engl J Med 2011 Aug 28 PMID: [7]
5. Goldhaber SZ et al Apixaban versus Enoxaparin for Thromboprophylaxis in Medically Ill Patients N Engl J Med, November 13, 20 <PubMed> PMID: [8] <Internet> [9]

apixaban