Aphakia

From Anvita Health Wiki

Contents 1 Introduction 2 Epidemiology 3 Pathology 4 Genetics 5 More General Terms 6 Internet Database 7 References

Introduction

• Congenital absence of the crystalline lens of the eye

Epidemiology

• rare

Pathology

• early developmental arrest, around the 4th-5th week of gestation that prevents formation of any lens structure & leads to severe secondary ocular defects, including aplasia of anterior segment of eye (primary congenital aphakia)
• in secondary aphakia, lens induction has occurred, & lens vesicle has developed to some degree but finally has progressively resorbed perinatally resulting in less-severe ocular defects * lens development requires initial presence of a lens

Genetics

• associated with defects in FOXE3 gene

More General Terms

• eye disease (ophthalmopathy)
• developmental disorder

Internet Database

OMIM: 610256

References

1. Dorland's Medical Dictionary, 23rd ed., WB Saunders, Philadelphia, 1990
2. OMIM [1]

aphakia