Apbb1 Interacting Protein 1

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 More General Terms 6 Internet Database 7 References

Function

• role in signal transduction from Ras activation to actin cytoskeletal remodelling
• suppresses insulin-induced promoter activities through AP1 & SRE
• mediates Rap1-induced adhesion
• interacts, through the N-terminal Pro-rich region, with WW domain of APBB1
• interacts with RAP1A, PFN1, VASP & ENAH

Structure

• belongs to the MRL family
• contains 2 Pro-rich regions required for suppression of AP1 transcription activity
• contains 1 PH domain
• contains 1 Ras-associating domain

Compartment

• cell membrane
• colocalizes with ENA/VASP proteins at lamellipodia tips & focal adhesions, & F-actin at the leading edge
• at the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns[5]P & PtdIns[3]P - necessary for efficient interaction of RA domain with Ras-GTPases

Expression

• widely expressed
• high expression in thymus, spleen, lymph node, bone marrow & peripheral leukocytes
• induced by all-trans-retinoic acid

More General Terms

• membrane protein

Internet Database

Prosite: [1]
UniProt: [2]

References

UniProt [3]

APBB1-interacting protein 1 (amyloid beta A4 precursor protein-binding family B member 1-interacting protein, Rap1-GTP-interacting adapter molecule, RIAM, Proline-rich EVH1 ligand 1, PREL-1, proline-rich protein 73, retinoic acid-responsive proline-rich protein 1, RARP-1, APBB1IP, PREL1, RARP1, RIAM)