Antithrombin Iii
From Anvita Health Wiki
Contents |
More Specific Terms
Function
- most important serine protease inhibitor in plasma
- regulates the blood coagulation cascade
- inhibits thrombin, factors IXa, Xa & XIa
- inhibitory activity is greatly enhanced in the presence of heparin ( heparin cofactor)
- anti-inflammatory properties [2]
Structure
- belongs to the serpin family
Compartment
Expression
- found in plasma
Pathology
- defects in SERPINC1 are the cause of
- antithrombin III deficiency
- plasma activity may be reduced as a result of acute thrombosis
- anticoagulation does NOT lower activity of antithrombin III in plasma
Pharmacology
More General Terms
Additional Terms
Internet Database
OMIM: 107300
OMIM: 188050
Prosite: [1]
UniProt: [2]
References
- UniProt [3]
- antithrombin mutation db [4]
- GeneReviews [5]
- SHMPD;The Singapore human mutation andcpolymorphism database [6]
- Wikipedia; antithrombin entry [7]
