Antipsychotic Agent
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Contents |
More Specific Terms
- acamprosate (Campral, Alcomed)
- acetophenazine (Tindal, Phentoxate, Tindala)
- atypical antipsychotic agent
- chlorpromazine (Thorazine, Ormazine, Propaphenin, Sonazine, Chloractil)
- chlorprothixene (Taractan, Tarasan, Minithixen, Truxal)
- clozapine (Clozaril)
- deserpidine
- fluphenazine (Prolixin, Anatensol, Triflumethazine, Calmansial, Modecate)
- haloperidol (Haldol, Halperon, Aloperidol, Halomonth)
- loxapine (Loxitane, Dibenzoazepine, Cloxazepin)
- mesoridazine (Serentil, Calodal)
- molindone (Moban, Lindone)
- perphenazine (Trilafon)
- pimozide (Orap)
- thioridazine (Mellaril, Millazine, Melleretten)
- thiothixene (Navane, Tiotixene)
- trifluoperazine (Stelazine, Suprazine)
- triflupromazine (Vesprin, Flumazin)
Classification
- traditional
- high potency dopamine D2 receptor antagonist
- low potency dopamine D2 receptor antagonist
- atypical
Indications
Pharmacokinetics
- variable absorption
- highly bound to plasma proteins
- widely distributed to tissues including CNS
- metabolized by liver
- 1/2 of the dose excreted by liver, the other 1/2 through the enterohepatic circulation
Adverse-effects
- high potency dopamine D2 receptor antagonists
- low potency dopamine D2 receptor antagonists
-
- related to alpha-adrenergic receptor antagonism
- common side effects
- weight gain
- impotence
- skin manifestations
- pigmentary changes in skin
- photosensitivity
- decreased seizure threshold
- tardive dyskinesia
- long term usage
- generally irreversible
- 10-20% of patients
Notes
- Atypical antipsychotics may not be more effective than older agents in the treatment of schizophrenia. All agents are discontinued more frequently than not [4].
More General Terms
Additional Terms
References
- Saunders Manual of Medical Practice, Rakel (ed), WB Saunders, Philadelphia, 1996, pg 1147
- Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 712
- Sultzer, D. In: Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 12-15, 2001
- Lieberman JA et al. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med 2005 Sep 22; 353:1209-23. PMID: [1]
- Prescriber's Letter 12(9): 2005 Role of atypical antipsychotics in treating patients with Schizophrenia: Are they better than older agents? Detail-Document#: [2] (subscription needed) [3]
