Antiarrhythmic Agent Group Iv

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Contents 1 More Specific Terms 2 Introduction 3 More General Terms 4 Additional Terms 5 References

More Specific Terms

• verapamil (Isoptin, Calan, Verelan, Covera-HS, Iproveratril, Dilacorin, Cardioprotect)

Introduction

• Class IV agents are Ca+2-channel blockers. They selectively block the slow inward Ca+2 current, especially of the sinoatrial ( SA) node, the atrioventricular ( AV) node, & areas of disease myocardium dependent upon slow Ca+2-channel activity for conduction, attenuating conduction velocity & automaticity & prolonging refractoriness of these structures.

More General Terms

• antiarrhythmic agent

Additional Terms

• calcium channel blocker (CCB)

References

1. Manual of Medical Therapeutics, 28th ed, Ewald & McKenzie (eds), Little, Brown & Co, Boston, 1995, pg 161
2. Medical Knowledge Self Assessment Program (MKSAP) 15, American College of Physicians, Philadelphia 2009

antiarrhythmic agent, Group IV