Anti Rheumatoid Arthritis Nuclear Antigen

From Anvita Health Wiki

Contents 1 Etiology 2 Pathology 3 Clinical-significance 4 More General Terms 5 Additional Terms 6 References

Etiology

• originally found in patients with

• Sjogren's syndrome
• rheumatoid arthritis

• the antigen is also detected in B cells infected with Epstein Barr virus

Pathology

• nuclear distribution in a finely speckled pattern by immuno- fluorescence microscopy.

Clinical-significance

• anti-RANA is detected in 90% of patients with rheumatoid arthritis & in 6-25% of control subjects

More General Terms

• serology
• autoantibody
• antigen

Additional Terms

• rheumatoid arthritis (RA)
• Sjogren's syndrome (keratoconjunctivitis sicca, autoimmune epitheliitis)

References

Clinical Diagnosis & Management by Laboratory Methods, 19th edition, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1996, pg 1020

anti-rheumatoid arthritis-associated antigen (RANA)