Anti Keratin Antibody

From Anvita Health Wiki

Contents 1 Etiology 2 Clinical-significance 3 Methods 4 More General Terms 5 Additional Terms 6 References

Etiology

• rheumatoid arthritis

Clinical-significance

• 36-59% of patients with rheumatoid arthritis have anti-keratin antibody compared with 0-3% of healthy individuals
• anti-keratin antibody specificity

• AE1/ AE3: pankeratin
• AE1: CK10/CK11/ CK13/ CK14/ CK15/ CK16/ CK19 ( low molecular weight keratins)
• AE3: high molecular weight keratins
• CAM5.2: anti- keratin 8/18
• 35 beta H11: anti- keratin 18
• 34 beta E12 (CK903): CK1/ CK5/ CK10/ CK14

• basal cell specific
• basal cells of prostate

• spurious keratin immunoreactivity has been described in glial cells & neoplasms with AE1/ AE3 & 34 beta E12 antibodies.
• CAM 5.2 does not react with astroglial cells

Methods

• anti- keratin antibodies react against the stratum corneum of rat esophagus

More General Terms

• serology
• autoantibody

Additional Terms

• keratin
• rheumatoid arthritis (RA)

References

1. Clinical Diagnosis & Management by Laboratory Methods, 19th edition, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1996, pg 1020
2. Dabbs. Diagnostic Immunohistochemistry. Churchill-Livingstone, 2002. page 168, 174.

anti-keratin antibody