Anti Centromere Antibody

From Anvita Health Wiki

Contents 1 Etiology 2 Principle 3 Clinical-significance 4 Methods 5 Specimen 6 More General Terms 7 Additional Terms 8 References

Etiology

• present in 70-80% of patients with CREST syndrome
• present in 1% of patients with diffuse scleroderma

Principle

• originally detected by immunofluorescence microscopy with the antigen localized to the region of condensing metaphase chromosomes
• routinely detected via immunoblots
• centromere antigens consist of three proteins, of 16, 80 & 120 kD MW.

Clinical-significance

• no correlation between antibody titers & disease activity

Methods

• test is performed using cell lines such as Hep2

Specimen

• serum
• store at -20 degrees C

More General Terms

• serology
• special chemistry test
• autoantibody

Additional Terms

• centromere
• CREST syndrome

References

1. Clinical Diagnosis & Management by Laboratory Methods, 19th edition, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1996, pg 1019
2. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
3. Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995

anti-centromere antibody