Anti Adrenal Antibody

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Contents 1 Etiology 2 Clinical-significance 3 Methods 4 Specimen 5 More General Terms 6 Additional Terms 7 References

Etiology

• autoimmune adrenalitis

• idiopathic Addison's disease

Clinical-significance

• in autoimmune adrenalitis, anti-adrenal antibodies are of the IgG class & are directed against adrenocortical microsomes
• the test is used as a marker for idiopathic Addison's disease

• 50% of patients will have positive titers.

• adrenal autoantibodies are not seen with adrenal tumors, Cushing's disease, virilizing adrenal hyperplasia, or tuberculosis of the adrenal gland
• patients with autoimmune adrenalitis have a higher incidence of other organ-specific autoimmune diseases including:

• Grave's disease
• Hashimoto's thyroiditis
• insulin-dependent diabetes mellitus
• pernicious anemia
• ovarian failure

Methods

• ELISA
• complement fixation
• indirect immunofluorescence Interference:
• mitochondrial or ribosomal antibodies may interfere with the indirect immunofluorescence assay

Specimen

• serum

More General Terms

• serology
• autoantibody

Additional Terms

• adrenal (suprarenal) gland

References

Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed.,  W.B. Saunders, 1995

anti-adrenal antibody