Ankyrin Repeat

From Anvita Health Wiki

Contents 1 Introduction 2 More General Terms 3 Additional Terms 4 Internet Database 5 References

Introduction

• Tandemly repeated module of about 33 amino acid residues origionally identified as a site anchoring ankyrin to tubulin. It is present in transmembrane receptors, cytoskeletal proteins & transcription factors. It mediates protein-protein interactions crucial for intercellular signalling (4).

More General Terms

• binding site
• peptide motif
• consensus repeat

Additional Terms

• ankyrin
• ankyrin repeat domain protein (ANKRD)

Internet Database

Prosite: [1]

References

1. Thompson CC, Brown TA, McKnight SL. Convergence of Ets- and notch-related structural motifs in a heteromeric DNA binding complex. Science. 1991 Aug 16;253(5021):762-8. PMID: [2]
2. LaMarco K, Thompson CC, Byers BP, Walton EM, McKnight SL. Identification of Ets- and notch-related subunits in GA binding protein. Science. 1991 Aug 16;253(5021):789-92. PMID: [3]
3. Hoffman M. New role found for a common protein "motif". Science. 1991 Aug 16;253(5021):742. PMID: [4]
4. Pawson T Protein modules and signalling networks Nature 373:573 1995 (Notch) PMID: [5]

Notch/ankyrin repeat