Angiotensin Ii Receptor 1

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 Pathology 6 Polymorphism 7 More General Terms 8 Additional Terms 9 Internet Database 10 References

Function

• receptor for angiotensin II
• G protein-coupled receptor, activates a phosphatidylinositol- Ca+2 2nd messenger system
• C-terminal Ser or Thr may be phosphorylated

Structure

• belongs to the G-protein coupled receptor 1 family

Compartment

• cell membrane

Expression

• expressed in liver, lung, adrenal, adrenocortical adenomas

Pathology

• defects in AGTR1 are a cause of renal tubular dysgenesis

Polymorphism

• AGTR1 gene polymorphisms associated with hypertension

More General Terms

• angiotensin-2 receptor

Additional Terms

• angiotensin II
• type-1 angiotensin 2 receptor-associated protein (AT1 receptor-associated protein, AGTRAP, ATRAP)

Internet Database

Entrez gene: 185
Kegg: [1]
OMIM: 106165
OMIM: 267430
Prosite: [2]
Prosite: [3]
UniProt: [4]

References

1. UniProt [5]
2. Hunter T. Cooperation between oncogenes. Cell. 1991 Jan 25;64(2):249-70. Review. PMID: [6]
3. GeneReviews [7]
4. SHMPD; The Singapore human mutation and polymorphism database [8]
5. Wikipedia; Note: angiotensin receptor entry [9]

angiotensin II receptor type-1 (AGTR1, AT1, AT1AR, AT1BR, AGTR1A, AGTR1B, AT2R1, AT2R1B)