Ancient Ubiquitous Protein 1

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Alternative-splicing 5 Expression 6 More General Terms 7 Internet Database 8 References

Function

• may play a role in translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm & their degradation by the proteasome
• identified in a complex that contains SEL1L, OS9, FAF2/ UBXD8, UBE2J1/UBC6E & AUP1
• interacts with the cytoplasmic tail of ITGA2B, ITGA1, ITGA2, ITGA5, ITGAV & ITGAM

Structure

• belongs to the AUP1 family
• contains 1 CUE domain

Compartment

• endoplasmic reticulum membrane
• single-pass type 3 membrane protein; cytoplasmic side

Alternative-splicing

• named isoforms=3; long, short

Expression

• detected in blood platelets & leukocytes (at protein level)
• ubiquitous
• highly expressed in placenta, liver, kidney, skeletal muscle, heart & brain

More General Terms

• membrane protein
• phosphoprotein

Internet Database

Entrez gene: 550
Kegg: [1]
OMIM: 602434
Prosite: [2]
UniProt: [3]

References

UniProt [4]

Ancient ubiquitous protein 1 (AUP1)