Anakinra

From Anvita Health Wiki

Contents 1 Indications 2 Contraindications 3 Dosage 4 Mechanism-of-action 5 Notes 6 More General Terms 7 Additional Terms 8 References

Indications

• treatment of rheumatoid arthritis ( FDA approved 2001)

Contraindications

• concurrent use of other biologic agent ( TNF inhibitor, rituximab, abatacept)

Dosage

• 1-2 mg/kg SC in combination with methotrexate [3]

Mechanism-of-action

• interleukin-1 inhibitor
• pharmaceutical form of IL-1 receptor antagonist protein

Notes

• Manufacturer: Amgen

More General Terms

• anti-inflammatory agent
• disease-modifying antirheumatic agent (DMARD)

Additional Terms

• interleukin-1 (IL-1) or lymphocyte-activating factor
• interleukin-1 receptor antagonist protein; IL-1ra; IL-1RN; IRAP; IL1 inhibitor; ICIL-1RA (IL1RN, IL1F3, IL1RA)
• rheumatoid arthritis (RA)

References

1. Prescriber's Letter 9(2):S1 2002
2. Prescriber's Letter 9(3):13 2002
3. Journal Watch 22(9):70, 2002 Dayer J-M & Bresniban R, Arthritis Rheum 46:574, 2002
4. National Guideline Clearinghouse Anakinra for rheumatoid arthritis. (National Institute for Health and Clinical Excellence) ngc-guideline: [1]

anakinra (Kineret)