Amyloid

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Contents 1 More Specific Terms 2 Introduction 3 More General Terms 4 Additional Terms 5 References

More Specific Terms

• A4 amyloid peptide; beta-peptide
• ABri amyloid
• ADan amyloid
• AGel amyloid
• amylin, islet amyloid polypeptide [IAPP] or diabetes-associated peptide [DAP]
• amyloid protein AA
• amyloid protein SAA (serum amyloid protein-A)
• gamma-trace
• non-A-beta component of AD amyloid
• serum amyloid A-3
• serum amyloid A-4
• serum amyloid P component (SAP) or 9.5S alpha-1 glycoprotein

Introduction

• insoluble protein/peptide aggregates with a beta pleated sheet conformation. The beta-pleated sheet gives amyloid the characteristic insolubility & staining properties.

• Microscopic appearance/staining:

• hematoxylin & eosin: amorphous pink fibrillary aggregates
• Congo red: apple green birefringence seen with polarizing filter, orange red color without polarizing filter
• thioflavin T
• crystal violet (type of methyl violet): metachromatic staining

More General Terms

• protein

Additional Terms

• amyloidosis

References

Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 610

amyloid