Ampa Receptor

From Anvita Health Wiki

Contents 1 Introduction 2 Function 3 More General Terms 4 Internet Database 5 References

Introduction

• alpha-Amino-3-hydroxy-5-Methylisoxazole-4-Propionic Acid [AMPA] ionophore-linked receptor

Function

• the AMPA receptor appears to move in & out of synaptic membranes in a dynamic fashion [5]
• endocytosis of AMPA receptors

• may be associated with attenuation of excitatory neurotransmission
• stimulated by synaptic activity, ligand binding & insulin
• dependent on dynamin & phosphorylation/ phosphatases
• stimulus for endocytosis determines the fate on the AMPA receptors
• AMPA stimulation leads to a recycling endosome; insulin stimulation leads to degradation?

• potentiated by Zn+2.
• some variants may be somewhat permeable to Ca+2
• both AMPA & kainate are agonists [4]

More General Terms

• ionotropic glutamate receptor
• quisqualate receptor
• Na+ channel
• multisubunit protein

Internet Database

Prosite: [1]

References

1. Choi 1988
2. Manzoni OJ, Finiels-Marlier F, Sassetti I, Blockaert J, le Peuch C, Sladeczek FA. The glutamate receptor of the Qp-type activates protein kinase C and is regulated by protein kinase C. Neurosci Lett. 1990 Feb 5;109(1-2):146-51. PMID: [2]
3. Barnard EA. Receptor classes and the transmitter-gated ion channels. Trends Biochem Sci. 1992 Oct;17(10):368-74. Review. PMID: [3]
4. Lipton SA, Rosenberg PA. Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med. 1994 Mar 3;330(9):613-22. Review. No abstract available. PMID: [4]
5. Sheng M. Molecular organization of the postsynaptic specialization. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7058-61. Review. PMID: [5]

AMPA receptor or alpha glutamate receptor