Amobarbital

From Anvita Health Wiki

Contents 1 Introduction 2 Adverse-effects 3 Drug-interactions 4 Laboratory 5 More General Terms 6 Additional Terms 7 Internet Database 8 References

Introduction

• Sedative, hypnotic.

Adverse-effects

• coma
• respiratory arrest
• death
  
• drug adverse effects of anticonvulsants

Drug-interactions

• coadministration of valproic acid increases plasma barbiturate concentration
• coadminstration of ethanol or other CNS depressants increases effect
• barbiturates induce cyt P450 1A2, 2C9 & 3A4

• may diminish levels of drugs metabolized by cyt P450 1A2, 2C9 & 3A4
  

• drug interaction(s) of beta-adrenergic receptor antagonists with barbiturates

Laboratory

• specimen: serum
• methods: color, GLC, HPLC, EIA, RIA
• interferences:

• EIA, RIA: cross reactvity with other barbiturates

More General Terms

• barbiturate
• anticonvulsant

Additional Terms

• cytochrome p450 1A2 (cytochrome P3-450, phenacetin deethylase, cytochrome p450-4, CYP1A2)
• cytochrome P450 2C9; cytochrome P450 BP-1; cytochrome P450 MP-4; S-mephenytoin-4-hydroxylase; limonene 6-monooxygenase; limonene 7-monooxygenase (CYP2C9, CYP2C10)
• cytochrome P450 3A4 (cytochrome P450 C3, nifedipine oxidase, P450-PCN1, NF-25, CYP3A4)

Internet Database

PubChem: 6149
PubChem: 2163
PubChem: 2164

References

1. Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995
2. Prescriber's Letter 13(3): 2006 Cytochrome P450 drug interactions Detail-Document#: [1] (subscription needed) [2]

amobarbital (Amytal)