Amiloride Sensitive Sodium Channel Gamma

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Pathology 5 More General Terms 6 Internet Database 7 References

Function

• Na+ permeable non- voltage-sensitive ion channel gamma subunit
• phosphorylated on Ser & Thr
• ubiquitination targets individual subnits for endocytosis & proteasome-mediated degradation ( putative)
• interacts with the WW domains of NEDD4, NEDD4L, WWP1 & WWP2

Structure

• belongs to the amiloride-sensitive Na+ channel family

Compartment

• apical cell membrane; multi-pass membrane protein
• apical membrane of epithelial cells

Pathology

• defects in SCNN1G are a cause of Liddle syndrome

More General Terms

• transmembrane 2 protein
• amiloride sensitive Na+ channel subunit

Internet Database

Entrez gene: 6340
Kegg: [1]
OMIM: 177200
OMIM: 600761
Prosite: [2]
UniProt: [3]

References

1. UniProt [4]
2. GeneReviews [5]

amiloride-sensitive Na+ channel subunit gamma; epithelial Na+ channel subunit gamma; gamma-ENaC; SCNEG; nonvoltage-gated Na+ channel 1 subunit gamma; gamma-NaCH (SCNN1G)