Amiloride Sensitive Sodium Channel

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 More General Terms 5 Internet Database 6 References

Function

• non voltage-gated Na+ channel
• mediates electrodiffusion of sodium through apical membrane of epithelial cells
• controls resporption of sodium in kidney lung, sweat glands
• role in taste perception
  

• Inhibition:

• inhibited by amiloride

Structure

• heterotetramer consisting of two alpha, one beta & one gamma subunit
• alternative form with delta, replacing an alpha subunit

Compartment

• apical cell membrane

More General Terms

• Na+ channel
• plasma membrane protein
• multisubunit protein

Internet Database

OMIM: 601328

References

1. OMIM [1]
2. Uniprot P51170

amiloride-sensitive Na+ channel or lung Na+ channel