Amiloride

From Anvita Health Wiki

Contents 1 Introduction 2 Indications 3 Dosage 4 Adverse-effects 5 Drug-interactions 6 Mechanism-of-action 7 More General Terms 8 Internet Database 9 References

Introduction

• Tradename: Midamor.

Indications

• Lithium-induced nephrogenic diabetes insipidus

Dosage

• 5-10 mg PO QD

• Tabs: 5 mg.

Adverse-effects

• hyperkalemia

Drug-interactions

• hyperkalemia potentiated by concomitant use of ACE inhibitors, NSAIDs, diabetes.
  
• drug interaction(s) of antiarrhythmic agents in combination with diuretics
• drug interaction(s) of spironolactone with potassium-sparing diuretics
• drug interaction(s) of diuretics with angiotensin II receptor antagonists
• drug interaction(s) of diuretics with ACE inhibitors
• drug interaction(s) of NSAIDs, diuretics & angiotensin II receptor antagonists
• drug interaction(s) of NSAIDs, diuretics & ACE inhibitors

Mechanism-of-action

• inhibits collecting duct lumenal Na+ channel
• blocks uptake of Li+ by the distal tubule & collecting duct
• mild extracellular fluid volume contraction
• increased Na+ & H2O absorption at the proximal tubule
• decreased urine volume

More General Terms

• K+ sparing diuretic

Internet Database

PubChem: 16231
PubChem: 68540
PubChem: 16230
PubChem: 657389

References

1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
2. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 625

amiloride (Midamor, Amipramidin, Modamide)