Alpha Iduronidase

From Anvita Health Wiki

Contents 1 More Specific Terms 2 Function 3 Structure 4 Compartment 5 Expression 6 Pathology 7 More General Terms 8 Internet Database 9 References

More Specific Terms

• Aldurazyme (alpha-L-iduronidase)

Function

• hydrolysis of unsulfated alpha-L-iduronosidic linkages in dermatan sulfate

Structure

• monomer (probable)
• belongs to the glycosyl hydrolase 39 family

Compartment

• lysosome

Expression

• ubiquitous

Pathology

• defects in IDUA are the cause of

• Hurler-Scheie syndrome
• Hurler syndrome

• Also see Aldurazyme

More General Terms

• iduronidase
• metabolic agent (metabolic modifier)

Internet Database

OMIM: 252800
OMIM: 607014
OMIM: 607015
OMIM: 607016
Prosite: [1]
UniProt: [2]

References

1. UniProt [3]
2. Prescriber's Letter 11(2):suppl 2004
3. GeneReviews [4]

alpha-L-iduronidase (laronidase, Aldurazyme, IDUA)