Alpha 1 Antitrypsin

From Anvita Health Wiki

Contents 1 Function 2 Pharmacology 3 Indications 4 Dosage 5 Adverse-effects 6 More General Terms 7 Additional Terms 8 Internet Database 9 References

Function

• constitutes 90% of serum antitrypsin activity although relatively inactive towards trypsin
• its main function is to inactivate lysosomal elastase released upon phagocytosis of particles by neutrophils
• it passes through capillary walls
• alpha-1 antitrypsin normally accounts for 70% of alpha-1 band on serum protein electrophoresis

Pharmacology

• 
  

• Available only through specialty pharmacies
• Tradename: Prolastin, Zemaira, Aralast

Indications

• alpha-1 antitrypsin deficiency

Dosage

• 60 mg/kg IV once weekly

• Injection: > 20 mg alpha-1 antitrypsin/ mL (vials 500 & 1000 mg)

Adverse-effects

• uncommon (< 1%)

• dizziness, lightheadedness, leukocytosis, fever (< 102 F) delayed 12 hours after treatment

More General Terms

• acute phase protein
• alpha 1 globulin
• serine protease inhibitor; serpin
• glycoprotein
• metabolic agent (metabolic modifier)

Additional Terms

• alpha-1 antitrypsin deficiency

Internet Database

Prosite: [1]
UniProt: [2]
OMIM: 107400

References

1. Fundamentals of Clinical Chemistry 3rd ed., N.W. Teitz ed., W.B. Saunders, 1988, pg 330
2. Kaiser Permanente Northern California Regional Drug Formulary, 1998
3. Prescriber's Letter 11(2):suppl 2004

alpha-1 antitrypsin (alpha-1 protease inhibitor, contrapsin, Aralast, Zemaira, Prolastin)