Alpha 1 6 Mannosylglycoprotein 6 Beta N Acetylglucosaminyltransferase B
From Anvita Health Wiki
Contents |
Function
- glycosyltransferase, role in glycosylation
- acts on alpha-linked mannose of N-glycans & O-mannosyl glycans
- catalyzes transfer of N-acetylglucosamine ( GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAcbeta1,2-Manalpha on both the alpha1,3- & alpha1,6- linked mannose arms in the core structure of N-glycan
- also acts on GlcNAcbeta1,2-Manalpha1-Ser/ Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan
- role in modulating integrin & laminin-dependent adhesion & migration of neuronal cells via its activity in the O-mannosyl glycan pathway
- Cofactor: divalent metal cations (controversial)
Structure
- belongs to the glycosyltransferase 18 family
Compartment
- Golgimembrane
Alternative-splicing
- named isoforms=4
Expression
More General Terms
Additional Terms
Internet Database
UniProt: [1]
References
UniProt [2]
