Alpha 1 3 Mannosyltransferase Alg2

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Alternative-splicing 5 Pathology 6 More General Terms 7 Additional Terms 8 Internet Database 9 References

Function

• mannosylates man(2)GlcNAc(2)- dolichol diphosphate & man(1)GlcNAc(2)- dolichol diphosphate to form man(3)GlcNAc(2)- dolichol diphosphate
• protein modification; protein glycosylation

Structure

• belongs to the glycosyltransferase group 1 family glycosyltransferase 4 subfamily

Compartment

• membrane ( potential)

Alternative-splicing

• named isoforms=2

Pathology

• defects in ALG2 are the cause of congenital disorder of glycosylation type 1I

More General Terms

• membrane protein
• glycosyltransferase

Additional Terms

• congenital disorder of glycosylation type 1H

Internet Database

Entrez gene: 85365
Kegg: [1]
OMIM: 607905
OMIM: 607906
UniProt: [2]

References

1. UniProt [3]
2. GeneReviews [4]
3. GGDB; Note: glycogene database [5]

alpha-1,3/1,6-mannosyltransferase ALG2; asparagine-linked glycosylation protein 2 homolog; GDP-man:man(1)GlcNAc(2)-PP-dol alpha-1,3-mannosyltransferase; GDP-man:man(1)GlcNAc(2)-PP-dolichol mannosyltransferase; GDP-man:man(2)GlcNAc(2)-PP-dol alpha-1,6-mannosyltransferase (ALG2)