All Trans Retinol 13 14 Reductase

From Anvita Health Wiki

Contents 1 Function 2 Compartment 3 Alternative-splicing 4 More General Terms 5 Internet Database 6 References

Function

• retinol saturase, metabolism of vitamin A
• saturation of the 13-14 double bond of all-trans-retinol to produce all-trans-13,14-dihydroretinol
• activity toward all-trans- retinol as substrate
• does NOT use all-trans-retinoic acid nor 9-cis-retinol, 11-cis-retinol or 13-cis-retinol isomers as substrates
  

• Cofactor: NAD, NADP, or FAD

Compartment

• endoplasmic reticulum membrane, peripheral membrane

Alternative-splicing

• named isoforms=2

More General Terms

• flavoprotein
• oxidoreductase
• membrane protein

Internet Database

UniProt: [1]

References

UniProt [2]

all-trans-retinol 13,14-reductase (all-trans-13,14-dihydroretinol saturase, RetSat)