Alkylating Agent

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Contents 1 More Specific Terms 2 Adverse-effects 3 More General Terms 4 Additional Terms 5 References

More Specific Terms

• alkylating agent nitrosourea
• bendamustine (Treanda, Cytostasan, Ribomustin)
• busulfan (Myleran)
• carboplatin (CDBCA, Paraplatin)
• chlorambucil (Leukeran)
• cisplatin (Platinol)
• cyclophosphamide (Cytoxan, Neosar, Procytox {Canadian}) [CPM, CTX, CYT, NSC 26271]
• dacarbazine (DTIC)
• ifosfamide (Ifex, Friedman acid)
• mechlorethamine; nitrogen mustard (Mustargen, Nor-mustard, Chlorethazine)
• melphalan (Alkeran, L-PAM, L-sarcolysin phenylalanine mustard)
• phenoxybenzamine (Dibenzyline)
• procarbazine (Matulane, Natulan, ibenzmethyzin)
• streptozocin (Zanosar)
• temozolomide (Temodar, Methazolastone)
• thiotepa; thiophosphamide (Tespa, Thioplex)

Adverse-effects

• increased incidence of acute myelocytic leukemia ( AML)

• often preceded by myelodysplastic syndrome
• peak incidence 4-6 years after alkylating agent therapy

• non-random cytogenetic abnormalities

• chromosome 7 deletions
• trisomy 8
  

• drug adverse effects of alkylating agents

More General Terms

• pharmaceutical agent

Additional Terms

• alkylating agent combination

References

Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998

alkylating agent