Aldurazyme

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Contents 1 Introduction 2 Indications 3 Mechanism-of-action 4 More General Terms 5 References

Introduction

• Tradename: Aldurazyme ( FDA approved 2003)

Indications

• mucopolysaccharidosis 1

Mechanism-of-action

• enzyme replacement therapy
• hydrolysis of unsulfated alpha-L-iduronosidic linkages in dermatan sulfate

More General Terms

• alpha-L-iduronidase (laronidase, Aldurazyme, IDUA)
• metabolic agent (metabolic modifier)

References

1. UniProt [1]
2. Prescriber's Letter 11(2):suppl 2004

Aldurazyme (alpha-L-iduronidase)