Aldehyde Dehydrogenase Microsomal

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Alternative-splicing 5 Pathology 6 More General Terms 7 Internet Database 8 References

Function

• catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids
• active on a variety of saturated & unsaturated aliphatic aldehydes between 6 & 24 carbons in length
  

• an aldehyde + NAD+ + H2O <--> an acid + NADH
  

Structure

• belongs to the aldehyde dehydrogenase family

Compartment

• endoplasmic reticulum membrane, cytoplasmic side

Alternative-splicing

• named isoforms=2

Pathology

• defects in ALDH3A2 are the cause of Sjoegren-Larsson syndrome

More General Terms

• aldehyde dehydrogenase
• membrane protein

Internet Database

Kegg: [1]
OMIM: 270200
Prosite: [2]
Prosite: [3]
UniProt: [4]
Entrez gene: 224

References

1. UniProt [5]
2. GeneReviews [6]

aldehyde dehydrogenase 3 family, member A2 (aldehyde dehydrogenase 10, microsomal aldehyde dehydrogenase, ALDH3A2, ALDH10 FALDH)