Adenyl Cyclase 2

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 More General Terms 6 Internet Database 7 References

Function

• membrane-bound, calmodulin-insensitive adenylyl cyclase
• insensitive to Ca+2/ calmodulin
• stimulated by protein kinase C, Gs-alpha[GTP] & G-beta/gamma ( putative)

• ATP <--> 3',5'- cyclic AMP + diphosphate
  
• Cofactor: binds 2 Mg+2 per subunit ( putative)

Structure

• belongs to the adenylyl cyclase class-4/ guanylyl cyclase family
• contains 2 guanylate cyclase domains

Compartment

• membrane

Expression

• expressed in brain
• richest source is cerebellum

More General Terms

• adenyl cyclase, adenylyl cyclase or adenylate cyclase
• glycoprotein
• membrane protein

Internet Database

Kegg: [1]
OMIM: 103071
Prosite: [2]
Prosite: [3]
UniProt: [4]
Entrez gene: 108

References

1. Bakalyar & Reed Science 250:1403 1990
2. Cooper et al Adenylyl cyclases and the interaction between calcium and cAMP signalling. Nature 374:421 1995 PMID: [5]
3. UniProt [6]

adenyl cyclase-2 (ATP pyrophosphate-lyase 2, ADCY2, KIAA1060)