Adenosine Kinase

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Alternative-splicing 4 Expression 5 More General Terms 6 Internet Database 7 References

Function

• ATP dependent phosphorylation of adenosine & other related nucleoside analogs to monophosphate derivatives
• potential regulator of concentrations of extracellular adenosine & intracellular adenine nucleotides
• urine metabolism; AMP biosynthesis via salvage pathway
• AMP from adenosine: step 1/1
  

• ATP + adenosine <--> ADP + AMP
  
• Cofactor: binds 3 Mg+2 per subunit

Structure

• monomer
• belongs to the carbohydrate kinase pfkB family

Alternative-splicing

• named isoforms=2

Expression

• widely expressed
• highest level in placenta, liver, muscle & kidney

More General Terms

• kinase or ATP-phosphotransferase

Internet Database

OMIM: 102750
Prosite: [1]
Prosite: [2]
UniProt: [3]
Entrez gene: 132

References

1. UniProt [4]
2. PMID: [5]

adenosine kinase (adenosine 5'-phosphotransferase, ADK)