Activin Receptor 2b

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Alternative-splicing 5 Pathology 6 More General Terms 7 Internet Database 8 References

Function

• on ligand binding, forms a receptor complex consisting of two type 2 & two type 1 transmembrane Ser/Thr kinases
• type 2 receptors phosphorylate & activate type 1 receptors which autophosphorylate, then bind & activate SMAD ( SMAD2 & SMAD3 transcriptional regulators
• receptor for activin A, activin B & inhibin A
• interacts with myostatin [3]
  

• Cofactor: Mg+2 or Mn+2 ( putative)

Structure

• belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
• contains 1 protein kinase domain

Compartment

• membrane

Alternative-splicing

• named isoforms=2

Pathology

• defects in ACVR2B are a cause of left-right axis malformations

More General Terms

• activin receptor
• glycoprotein
• serine/threonine kinase

Internet Database

Kegg: [1]
OMIM: 602730
Prosite: [2]
Prosite: [3]
Prosite: [4]
UniProt: [5]
Entrez gene: 93

References

1. UniProt [6]
2. GeneReviews [7]
3. Joulia-Ekaza D, Cabello G. The myostatin gene: physiology and pharmacological relevance. Curr Opin Pharmacol. 2007 Jun;7(3):310-5. Epub 2007 Mar 19. Review. PMID: &dopt=Abstract

activin receptor type-2B; activin receptor type IIB; ACTR-IIB (ACVR2B)