Activin Receptor 2

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 More General Terms 5 Internet Database 6 References

Function

• by analogy with the TGF-beta receptor system, it is likely that the type 2 activin receptor is a constitutively active kinase [2]
• phosphorylates type 1 activin receptor which subsequently intiates intracellular signalling [2]
• on ligand binding, forms a receptor complex consisting of two type II & two type I transmembrane serine/threonine kinases
• type II receptors phosphorylate & activate type I receptors which autophosphorylate, then bind & activate SMAD transcriptional regulators
• receptor for activin A, activin B & inhibin A
• interacts with AIP1
• part of a complex consisting of AIP1, ACVR2A, ACVR1B & SMAD3 ( putative)
  

• Cofactor: Mg+2 or Mn+2 ( putative)

Structure

• belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
• contains 1 protein kinase domain

Compartment

• membrane

More General Terms

• activin receptor

Internet Database

Kegg: [1]
OMIM: 102581
Prosite: [2]
Prosite: [3]
Prosite: [4]
UniProt: [5]

References

1. Matzuk MM et al Different phenotypes for mice deficient in either activins or activin receptor type II. Nature 374:356 1995 PMID: [6]
2. Smith J Developmental biology. Angles on activin's absence. Nature 374:311 1995 PMID: [7]
3. UniProt [8]
4. CGP resequencing studies [9]

activin receptor 2A; activin receptor type IIA; ACTR-IIA; ACTRIIA (ACVR2A, ACVR2)