Abiraterone Acetate

From Anvita Health Wiki

Contents 1 Indications 2 Dosage 3 Adverse-effects 4 Mechanism-of-action 5 More General Terms 6 Internet Database 7 References

Indications

• treatment of castration-resistant prostate cancer

Dosage

• 1000 mg QD

Adverse-effects

• syndrome of secondary mineralocorticoid excess

• hypokalemia
• hypertension
• fluid overload

Mechanism-of-action

• inhibits CYP17

More General Terms

• enzyme inhibitor
• antineoplastic agent (chemotherapeutic agent)

Internet Database

PubChem: 132970
PubChem: 9821849

References

1. Attard G et al Selective inhibition of CYP17 with abiraterone acetate is highly active in the treatment of castration-resistant prostate cancer. J Clin Oncol 2009 Aug 10; 27:3742. PMID: [1]
2. Reid AHM et al. Significant and sustained antitumor activity in post-docetaxel, castration-resistant prostate cancer with the CYP17 inhibitor abiraterone acetate. J Clin Oncol 2010 Feb 16; [e-pub ahead of print] Not yet indexed in PubMe [2]

abiraterone acetate