85 Kd Calcium Independent Phospholipase A2
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Contents |
Function
- catalyzes the release of fatty acids from phospholipids
- implicated in
- normal phospholipid remodeling
- nitric oxide-induced or vasopressin-induced arachidonic acid release
- leukotriene & prostaglandin production
- may participate in Fas mediated apoptosis
- may participate in regulating transmembrane ion flux in glucose-stimulated B-cells
- role in cardiolipin deacylation
- isoform ankyrin-iPLA2-1 & isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity
- phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate
Structure
- forms large oligomeric 270-350 kD structures
- contains 7 ANK repeats
Compartment
Alternative-splicing
Expression
- four different transcripts expressed in a distinct tissue distribution
Pathology
- defects in PLA2G6 are the cause of
Pharmacology
- potential target for therapeutic intervention of Barth syndrome
More General Terms
- phospholipase A2; phosphatidylcholine 2-acylhydrolase (PLA2)
- ankyrin repeat domain protein (ANKRD)
- phosphoprotein
Internet Database
Entrez gene: 8398
Kegg: [1]
OMIM: 256600
OMIM: 603604
OMIM: 610217
OMIM: 612953
Prosite: [2]
Prosite: [3]
UniProt: [4]
References
