5 6 Dihydroxyindole 2 Carboxylic Acid Oxidase

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 Pathology 6 More General Terms 7 Additional Terms 8 Internet Database 9 References

Function

• oxidation of 5,6-dihydroxyindole-2- carboxylic acid (DHICA) into indole-5,6- quinone-2- carboxylic acid
• may regulate or influence the type of melanin synthesized
• pigment biosynthesis; melanin biosynthesis
  

• Cofactor: binds 2 copper ions per subunit ( putative)

Structure

• belongs to the tyrosinase family

Compartment

• melanosome membrane

Expression

• pigment cells

Pathology

• defects in TYRP1 are the cause of

• Rufous oculocutaneous albinism
• oculocutaneous albinism type 3

More General Terms

• oxidoreductase
• membrane protein
• glycoprotein
• metalloprotein

Additional Terms

• tyrosinase (monophenol monooxygenase, tumor rejection antigen AB, SK29-AB, LB24-AB, TYR)

Internet Database

UniProt: [1]
Entrez gene: 7306
Kegg: [2]
OMIM: 115501
OMIM: 203290
OMIM: 278400
Prosite: [3]
Prosite: [4]

References

1. UniProt [5]
2. Mutations of the TYRP1 gene Note: Retina International's Scientific newsletter [6]
3. Albinism database (ADB); Note: TYRP1 mutations [7]

5,6-dihydroxyindole-2-carboxylic acid oxidase; DHICA oxidase; tyrosinase-related protein 1; TYRP1, catalase B; glycoprotein-75; gp75; brown [b] locus protein homolog; CAS2 protein; melanoma antigen gp75; monophenol monooxygenase homolog (TYRP1, CAS2, TYRP, TYRRP)