3 Oxo 5 Alpha Steroid 4 Dehydrogenase 3

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 Pathology 6 More General Terms 7 Internet Database 8 References

Function

• converts testosterone into 5-alpha- dihydrotestosterone
  

• 3-oxo-5-alpha- steroid + acceptor <--> 3-oxo-delta(4)- steroid + reduced acceptor

Structure

• belongs to the steroid 5-alpha reductase family

Compartment

• microsome membrane

Expression

• almost no or little expression in normal adult organs

Pathology

• overexpressed in hormone- refractory prostate cancers

More General Terms

• 3-oxo-5-alpha-steroid 4 dehydrogenase; steroid 5-alpha reductase
• membrane protein

Internet Database

Kegg: [1]
Prosite: [2]
UniProt: [3]

References

UniProt [4]

3-oxo-5-alpha-steroid 4-dehydrogenase 3 (steroid 5-alpha-reductase 3, SR type 3, steroid 5-alpha-reductase 2-like, SRD5A3, SRD5A2L)