3 Keto Steroid Reductase
From Anvita Health Wiki
Contents |
Function
- reduction of the keto group on the C-3 of sterols
- estrogens biosynthesis
- sterols biosynthesis
- phosphorylated
* 4-alpha-methyl-5-alpha-cholest-7-en-3-beta-ol + NADP+ * <--> * 4-alpha-methyl-5-alpha-cholest-7-en-3-one + NADPH * Estradiol-17-beta + NADP+ <--> estrone + NADPH
Compartment
- membrane
Alternative-splicing
- named isoforms=3
Expression
- expressed in adrenal gland, liver, lung, thymus > breast, ovaries, pituitary gland, pregnant uterus, prostate, kidney, lymph node, small intestine, spinal cord, trachea > other tissues
- isoform 3 is expressed in eye ciliary epithelial cells & neuroendocrine cells
More General Terms
Internet Database
OMIM: 606756
Prosite: [1]
UniProt: [2]
References
UniProt [3]
